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US 9,006,424 B2Granted
Process for the manufacture of ivabradine and of intermediates of synthesis thereof
AssigneeLaboratorio Chimico Internazionale S.p.A.
InventorsAntonio Nardi, Bruno De Angelis, Paolangelo Cerea, Jane Llorenc Rafecas, Nicolas Tesson
Life of this patent
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Abstract
The invention concerns a new process for the resolution of ivabradine and of intermediates of synthesis thereof.
Claims8
Process for the preparation of a compound of formula (A) in its (S) form
- wherein R is hydrogen or methyl and R′ is hydrogen or a group of formula (IV)
- which comprises
- (i) reacting a compound of formula (A) in racemic form with (S)-ibuprofen, in an organic solvent;
- (ii) stirring the solution at room temperature until a precipitate occurs;
- (iii) treating the precipitate formed in step (ii) with a base to release compound (A) in its (S) form;
- and
- (iv) optionally isolating the compound of formula (A) in its (S) form.
4 more elements
(S)-ibuprofenate of (1S)-4,5-dimethoxy-1-(ammoniummethyl)-benzocyclobutane.(S)-ibuprofen having the following formula (C)
Dependencies are inferred from the claim text.