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US 9,006,417 B2Granted
Non-liposomal systems for nucleic acid delivery
AssigneeProtiva Biotherapeutics, Inc.
InventorsEd Yaworski, Lloyd B. Jeffs, Lorne R. Palmer
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Abstract
The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
Claims24
A composition comprising:
- a plurality of nucleic acid-lipid particles, wherein each particle in the plurality of particles comprises:
- (a) a nucleic acid;
- (b) a cationic lipid comprising from about 50 mol % to about 85 mol % of the total lipid present in the particle;
- (c) a non-cationic lipid comprising from about 13 mol % to about 49.5 mol % of the total lipid present in the particle;
- and
- (d) a conjugated lipid that inhibits aggregation of particles comprising from about 0.5 mol % to about 10 mol % of the total lipid present in the particle,
- wherein at least about 95% of the particles in the plurality of particles have a non-lamellar morphology.
4 more elements
Dependencies are inferred from the claim text.