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US 9,006,391 B2Granted
Method for the preparation of cyclopeptides
AssigneeDSM Sinochem Pharmaceuticals Netherlands B.V.
InventorsRobertus Mattheus De Pater, Dhiredj Chandre Jagesar, Thomas Van Der Does
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Abstract
The present invention relates to a method for preparing cyclopeptides by means of protection with a substituted boronic acid. The present invention also discloses novel boronate esters of cyclopeptides of general formula (8).
Claims3
A compound of the general formula (8)
- wherein R1 is C(O)R2,
- R2 is C9-C21 alkyl, C9-C21 alkenyl, C1-C10 alkoxyphenyl, C1-C10 alkoxynaphthyl or C1-C10 alkoxyterphenyl,
- R3 is benzimidazol-2-yl, benzothiazol-2-yl, 1-methylimidazol-2-yl, 4-methoxyphenyl or phenyl,
- R4 is OH or —SR3,
- R5 is cyclohexyl, or 4-tert-butylphenyl,
- X is O or H,H.
3 more elements
Dependencies are inferred from the claim text.