Synthesis polyesters with precisely sequenced two or more structural units
AssigneeMolecon, Inc.
InventorBin Huang
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Abstract
The present invention related to compositions and methods of producing polyesters with two and/or more different structural units and the materials of polyesters with structure sequence exactly specified therefore produced, and various articles produced from such exactly sequenced polyesters. More particularly, homogeneous copolymers with precisely defined sequences of various hydroxyl acids and their derivatives are produced according to the present invention.
Claims19
A polymer of poly(hydroxy acids) with two or more precisely sequenced hydroxyacid structural units, said polymer having Formula (XI):
- wherein R1, R2 . . . Rm and R′1, R′2 . . . R′m are members independently selected in each structural unit from the group consisting of H, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, unsubstituted heteroaryl, substituted alkoxy, unsubstituted alkoxy, amide, ester, nitro, amine and thiol;
- X′ is F, Cl, Br, or I;
- m is a positive integer greater than 1;
- n is a positive integer greater than 1;
- and
- t1, t2, . . . tm are independently 0 or a positive integer;
- wherein at least one of R1, R2 . . . Rm and R′1, R′2 . . . R′m is other than ester, nitro, amine or thiol, and wherein at least one of the hydroxyacid units is different from the others.
A method for preparing a polymer of poly(hydroxy acids) with two or more precisely sequenced structural units, comprising the steps of:
- (a) Preparing an oligomer with two or more precisely sequenced structural units of Formula (x):
- wherein R1, R2 . . . Rm and R′1, R′2 . . . R′m are members independently selected in each structural unit from the group consisting of H, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, unsubstituted heteroaryl, substituted alkoxy, unsubstituted alkoxy, amide, ester, nitro, amine and thiol;
- X′ is F, Cl, Br, or I;
- m is a positive integer greater than 2;
- and
- t1, t2, . . . tm are independently 0 or a positive integer;
- (b) polymerizing the said halocarboxylic acid oligomers of Formula (X) in an organic solvent at a reaction temperature between −20 and 200° C. to generate said polymer, wherein said polymerizing step is performed in a controlled manner in the presence of a base, said base being an alkyl amine, or a 5- or 6-membered aromatic heterocycle comprising at least one endocyclic nitrogen atom;
- and
- (c) recovering said polymer.
Dependencies are inferred from the claim text.