Temperature-sensitive polyethylene glycol / polyester block copolymer in which bioactive functional group is introduced into side chain thereof

A temperature-sensitive polyethylene glycol/polyester block copolymer comprising:

• a hydrophilic moiety comprising polyethylene glycol;
• and
• a polyester-based hydrophobic moiety of Chemical Formula 1 comprising a caprolactone segment and a lactide segment having a bioactive functional group R introduced into a side chain thereof:
• wherein
• x and y are mole fractions of the caprolactone segment and the lactide segment having the bioactive functional group R introduced, with x/y being from 0.01/99.99 to 99.99/0.01, and
• R is —CH2O—R1—NH2, —CH2O—R1—NH—R1—NH2, —CH2O—R1—NH-peptide, Arg-Gly-Asp, Gly-Pro-Glu, Arg-Gly-Asp-Ser, Gly-Gly-Ala, Gly-Arg-Gly-Asp-Ser, Gly-Arg-Gly-Asp-Thr-Pro, Gly-Arg-Gly-Asp-Ser-Pro, a protein comprising an amine structure or a polyamine having a molecular weight of 350-2,000 g/mole, and
• R has an amine group at the end of the molecular chain,
• wherein R1 is (C1-C20) alkylene with or without carbonyl, (C2-C20) alkenylene with or without carbonyl or (C2-C20) alkynylene with or without carbonyl and R2 is (C1-C20) alkyl with or without carbonyl, (C2-C20) alkenyl with or without carbonyl or (C2-C20) alkynyl with or without carbonyl.