Biocompatible material

A monomer of formula (I):

• wherein:
• W is (CR12)n;
• Z is a zwitterionic group selected from the group consisting of (IIA), (IIB), (IIC), (IID) and (IIE), wherein group (IIA) has the formula:
• wherein each R3 and R3A is independently selected from hydrogen and C1-4 alkyl and a is an integer from 2 to 4;
• group (IIB) has the formula:
• wherein each R4 and R4A is independently selected from hydrogen and C1-4 alkyl and b is an integer from 1 to 4;
• group (IIC) has the formula:
• wherein each R5 and R5C is independently selected from hydrogen and C1-4 alkyl;
• R5A is hydrogen or a group —C(O)B1R5B, wherein R5B is hydrogen or methyl, B1 is selected from the group consisting of a bond;
• C1-10 alkylene, C2-10 alkenylene, C2-10 alkynylene, C3-10 cycloalkylene, C3-10 cycloalkenylene, C1-10 heteroalkylene, C2-10 heteroalkenylene, C2-10 heteroalkynylene, arylene, heteroarylene, —C(O)RM—, —C(O)ORM—, wherein RM is selected from the group consisting of C1-10 alkylene, C2-10 alkenylene and C2-10 alkynylene, and wherein the alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, heteroalkylene, heteroalkenylene, heteroalkynylene, arylene and heteroarylene groups may be optionally substituted with one or more RN, wherein each RN is independently selected from the group consisting of —H, —OH, —CN, —NO2, —CF3, —OCF3, —CO2H, —NH2, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —O(C1-C10 alkyl), —O(C2-C10 alkenyl), —O(C2-C10 alkynyl), halogen, —C(O)H, —C(O)—(C1-C10 alkyl), —C(O)—O(C1-C10 alkyl), —NH(C1-C10 alkyl), —N(C1-C10 alkyl)2, —C(O)—NH(C1-C10 alkyl), —C(O)—N(C1-C10 alkyl)2, —NH—C(O)—(C1-C10 alkyl), —NH(C1-C10 alkyl)-C(O)—(C1-C10 alkyl), —NH—S(O)2—(C1-C10 alkyl), —NH—(C1-C10 alkyl)-S(O)2—(C1-C10 alkyl), —(C0-C10)—SH, —S(O)—(C1-C10 alkyl), —S(O)2—(C1-C10 alkyl), —S(O)2—NH2, —S(O)2—NH—(C1-C10 alkyl), —S(O)2—N(C1-C10 alkyl)2 and ═O, and c is an integer from 1 to 4, wherein if Z is directly bonded to an O or N atom, z is 0 and otherwise z is 1;
• group (IID) has the formula:
• wherein each R6 and R6C is independently selected from hydrogen and C1-4 alkyl;
• R6A is hydrogen or a group —C(0)B2R6B, wherein R6B is hydrogen or methyl, B2 is selected from the group consisting of a bond;
• C1-10 alkylene, C2-10 alkenylene, C2-10 alkynylene, C3-10 cycloalkylene, C3-10 cycloalkenylene, C1-10 heteroalkylene, C2-10 heteroalkenylene, C2-10 heteroalkynylene, arylene, heteroarylene, —C(O)RM—, —C(O)ORM—, wherein RM is selected from the group consisting of C1-10 alkylene, C2-10 alkenylene and C2-10 alkynylene, and wherein the alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, heteroalkylene, heteroalkenylene, heteroalkynylene, arylene and heteroarylene groups may be optionally substituted with one or more RN, wherein each RN is independently selected from the group consisting of —H, —OH, —CN, —NO2, —CF3, —OCF3, —CO2H, —NH2, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —O(C1-C10 alkyl), —O(C2-C10 alkenyl), —O(C2-C10 alkynyl), halogen, —C(O)H, —C(O)—(C1-C10 alkyl), —C(O)—O(C1-C10 alkyl), —NH(C1-C10 alkyl), —N(C1-C10 alkyl)2, —C(O)—NH(C1-C10 alkyl), —C(O)—N(C1-C10 alkyl)2, —NH—C(O)—(C1-C10 alkyl), —NH(C1-C10 alkyl)-C(O)—(C1-C10 alkyl), —NH—S(O)2—(C1-C10 alkyl), —NH—(C1-C10 alkyl)-S(O)2—(C1-C10 alkyl), —(C0-C10)—SH, —S(O)—(C1-C10 alkyl), —S(O)2—(C1-C10 alkyl), —S(O)2—NH2, —S(O)2—NH—(C1-C10 alkyl), —S(O)2—N(C1-C10 alkyl)2 and ═O, and d is an integer from 1 to 4, wherein if Z is directly bonded to an O or N atom, z is 0 and otherwise z is 1;
• group (IIE) has the formula:
• wherein each R7 and R7C is independently selected from hydrogen and C1-4 alkyl;
• R7A is hydrogen or a group —C(O)B2R7B, wherein R7B is hydrogen or methyl, B2 is selected from the group consisting of a bond;
• C1-10 alkylene, C2-10 alkenylene, C2-10 alkynylene, C3-10 cycloalkylene, C3-10 cycloalkenylene, C1-10 heteroalkylene, C2-10 heteroalkenylene, C2-10 heteroalkynylene, arylene, heteroarylene, —C(O)RM—, —C(O)ORM—, wherein RM is selected from the group consisting of C1-10 alkylene, C2-10 alkenylene and C2-10 alkynylene, and wherein the alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, heteroalkylene, heteroalkenylene, heteroalkynylene, arylene and heteroarylene groups may be optionally substituted with one or more RN, wherein each RN is independently selected from the group consisting of —H, —OH, —CN, —NO2, —CF3, —OCF3, —CO2H, —NH2, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —O(C1-C10 alkyl), —O(C2-C10 alkenyl), —O(C2-C10 alkynyl), halogen, —C(O)H, —C(O)—(C1-C10 alkyl), —C(O)—O(C1-C10 alkyl), —NH(C1-C10 alkyl), —N(C1-C10 alkyl)2, —C(O)—NH(C1-C10 alkyl), —C(O)—N(C1-C10 alkyl)2, —NH—C(O)—(C1-C10 alkyl), —NH(C1-C10 alkyl)-C(O)—(C1-C10 alkyl), —NH—S(O)2—(C1-C10 alkyl), —NH—(C1-C10 alkyl)-S(O)2—(C1-C10 alkyl), —(C0-C10)—SH, —S(O)—(C1-C10 alkyl), —S(O)2—(C1-C10 alkyl), —S(O)2—NH2, —S(O)2—NH—(C1-C10 alkyl), —S(O)2—N(C1-C10 alkyl)2 and ═O, and e is an integer from 1 to 4, wherein if Z is directly bonded to an O or N atom, z is 0 and otherwise z is 1;
• each R1 is independently selected from H, halogen or C1-4 alkyl;
• m is an integer from 0 to 6;
• and
• X is NR2;
• where R2, Y and the N atom to which they are bonded taken together form a 5 to 7 membered heterocyclic ring, wherein the heterocyclic ring may be optionally substituted with one or more RN, wherein each RN is independently selected from the group consisting of —H, —OH, —CN, —NO2, —CF3, —OCF3, —CO2H, —NH2, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —O(C)—(C1-C10 alkyl), —O(C2-C10 alkenyl), —O(C2-C10 alkynyl), halogen, —C(O)H, —C(O)—(C1-C10 alkyl), —C(O)—O(C1-C10 alkyl), —NH(C1-C10 alkyl), —N(C1-C10 alkyl)2, —C(O)—NH(C1-C10 alkyl), —C(O)—N(C1-C10 alkyl)2, —NH—C(O)—(C1-C10 alkyl), —NH(C1-C10 alkyl)-C(O)—(C1-C10 alkyl), —NH—S(O)2—(C1-C10 alkyl), —NH—(C1-C10 alkyl)-S(O)2—(C1-C10 alkyl), —(C0-C10)—SH, —S(O)—(C1-C10 alkyl), —S(O)2—(C1-C10 alkyl), —S(O)2—NH2, —S(O)2—NH—(C1-C10 alkyl), —S(O)2—N(C1-C10 alkyl)2 and ═O;
• n is an integer from 0 to 6;
• or
• X is NR2, where R2 is H or C1-4 alkyl;
• Y is —C(O)O— or —C(O)N(RM)—, where RM is H or C1-4 alkyl;
• and
• n is 0;
• or
• X is O;
• Y is —C(=V)A-;
• where V is S or O;
• and A is selected from NRM, O and S, where
• RM is hydrogen or C1-4 alkyl;
• and
• n is 0.