Composition and method for treatment of diabetes

A method of treating type I diabetes, type II diabetes, hypertriglyceridemia, obesity, appetite control, metabolic syndrome, polycystic ovary syndrome in an individual affected by a decrease or lack of release of a gut hormone secreted from L cells comprising stimulating the production of an L cell secreted gut hormone in the colon of the individual, the method comprising:

• a) selecting an omega-3 polyunsaturated fatty acid composition causing gut hormone secretion from L-cells, the composition formulated to release in a colon targeted delivery system or in a rectal release system;
• and
• b) administering sufficient composition to the individual colon or rectum sufficient to cause a release of gut hormones from the L-cell in the colon of the individual sufficient to achieve the desired result.