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US 9,006,283 B2Granted
Methods of modifying amyloid β oligomers using non-peptidic compounds
AssigneeAcumen Pharmaceuticals, Inc.
InventorsGrant A. Krafft, Todd Pray, William F. Goure
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Abstract
Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers from amyloid β1-42 monomers. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers.
Claims7
A method for antagonizing neurotoxic ADDL formation from monomeric Aβ1-42 by contacting monomeric Aβ1-42 with an effective amount of a compound selected from the group consisting of
- N-(2-Methoxy-phenyl)-2-oxo-2-{N′-[3-oxo-3-thiophen-2-yl-1-trifluoromethyl-prop-(Z)-ylidene]-hydrazino}-acetamide,
- 2-{[1-(2-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene-hydrazinooxalyl]-amino}-6-methyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester,
- 2-{[1-(2-Hydroxynaphthalen-1-yl)-meth-(E)-ylidene-hydrazinooxalyl]-amino}-6-methyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester,
- 2-{[1-(2-Hydroxyphenyl)-meth-(E)-ylidene-hydrazinooxalyl]-amino}-6-methyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester,
- 2-(5-hydroxy-3-isobutyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-N-(2-methoxyphenyl)-2-oxoacetamide,
- (E)-2-hydroxy-N′-((1-hydroxynaphthalen-2-yl)methylene)benzohydrazide,
- or a stereoisomer thereof or a mixture of the stereoisomers, or a pharmaceutical salt of the compound, stereoisomer or mixture.
4 more elements
Dependencies are inferred from the claim text.