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US 9,006,227 B2Granted
Modulators of cortical dopaminergic- and NMDA-receptor-mediated glutamatergic neurotransmission
AssigneeIntegrative Research Laboratories Sweden AB
InventorsClas Sonesson, Jonas Karlsson, Peder Svensson
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Abstract
The present invention relates to novel substituted phenoxyethylamine derivatives, useful as modulators of cortical and basal ganglia dopaminergic and N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims17
A phenoxy-ethyl-amine derivative of Formula 1
- a stereoisomer or a mixture of its stereoisomers, or an N-oxide thereof, or a deuterated analog thereof, or a pharmaceutically acceptable salt thereof, wherein
- R1 represents CH3 or CF3;
- R2 is selected from the group consisting of C1-C4-alkyl, allyl, CH2CH2OCH3, C(CH3)2CH2CH3, CH2-cyclopropyl, cyclobutyl, cyclopentyl, CH2CH2CH2F, CH2CH2CHF2, CH2CH2F, 3,3,3-trifluoropropyl and 4,4,4-trifluorobutyl;
- and
- R3 is selected from the group consisting of H, CH3 and CH2CH3;
- or
- R2 and R3 together form CH2(CH2)CH2 or CH2(CH2)3CH2;
- R4 represents F or Cl;
- and
- R′ and R″ independently represent hydrogen or methyl.
7 more elements
Dependencies are inferred from the claim text.