Stable pharmaceutical composition

A pharmaceutical composition comprising a type A crystal, type B crystal or mixtures thereof of 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionic acid as an active ingredient, together with at least one pharmaceutically acceptable carrier (A) and optionally other pharmaceutically acceptable carrier(s) (B),

• wherein the at least one pharmaceutically acceptable carrier (A) is selected from the group consisting of crystalline cellulose, mannitol, croscarmellose sodium, corn starch, anhydrous calcium hydrogenphosphate, sucrose, low substituted hydroxypropylcellulose, partially pregelatinized starch, hydroxypropylmethylcellulose, erythritol, polyvinyl alcohol, and carmellose calcium,
• (a) the composition does not substantially contain, as the pharmaceutically acceptable carrier, a reducing sugar and/or a carrier containing a reducing sugar as an ingredient, or
• (b) wherein when the pharmaceutically acceptable carrier(s) (B) is a reducing sugar or a carrier containing a reducing sugar as an ingredient, contact of the reducing sugar and said active ingredient is eliminated;
• wherein the type A crystal has characteristic peaks at 2θ of 6.9±0.2° 14.4±0.2° 16.4±0.2°, 18.2±0.2°, 25.0±0.2° and 27.5±0.2° in a powder X-ray diffraction spectrum, and
• wherein the type B crystal has characteristic peaks at 2θ of 14.4±0.2° 15.9±0.2° 17.3±0.2°, 22.2±0.2° and 22.9±0.2° in a powder X-ray diffraction spectrum.