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AssigneeSanten Pharmaceutical Co., Ltd.
InventorsYuko Shichijo, Atsuyoshi Dota, Takashi Nagano, Masatsugu Nakamura, Asuka Sakamoto
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An agent for treatment of dry eye comprising a combination of a P2Y2 receptor agonist at a therapeutically effective concentration and hyaluronic acid or a salt thereof at a therapeutically effective concentration, which agent has a dosage form of an ophthalmic agent, can promote the secretion of tear remarkably and can improve corneal epithelial disorders remarkably, and is therefore expected to be a novel agent for treatment of dry eye.
An ophthalmic solution for treating dry eye, characterized by comprising a combination of P1,P4-bis(5′-uridyl)tetraphosphate or a salt thereof at a concentration of 1 to 5% (w/v) and hyaluronic acid or a salt thereof at a concentration of 0.05 to 0.5% (w/v).
An ophthalmic solution for treating dry eye, characterized by comprising a combination of P1,P4-bis(5′-uridyl)tetraphosphate or a salt thereof at a concentration of 3% (w/v) and hyaluronic acid or a salt thereof at a concentration of 0.1 to 0.5% (w/v).
A method for treating dry eye, comprising administering P1,P4-bis(5′-uridyl)tetraphosphate or a salt thereof at a concentration of 1 to 5% (w/v) and hyaluronic acid or a salt thereof at a concentration of 0.05 to 0.5% (w/v) in combination to a patient in need thereof, wherein the dosage form is an ophthalmic solution.
A method for treating dry eye, comprising administering P1,P4-bis(5′-uridyl)tetraphosphate or a salt thereof at a concentration of 3% (w/v) and hyaluronic acid or a salt thereof at a concentration of 0.1 to 0.5% (w/v) in combination to a patient, wherein the dosage form is an ophthalmic solution.
A method for promoting tear secretion, comprising administering P1,P4-bis(5′-uridyl)tetraphosphate or a salt thereof at a concentration of 1 to 5% (w/v) and hyaluronic acid or a salt thereof at a concentration of 0.05 to 0.5% (w/v) in combination to a patient in need thereof having dry eye so as to promote tear secretion, wherein the dosage form is an ophthalmic solution.
Dependencies are inferred from the claim text.