Composition and methods for modulating cell proliferation and cell death
AssigneesRosetta Genomics Ltd., Yeda Research and Development Co. Ltd.
InventorsMoshe Oren, Nina Raver-Shapira, Efi Marciano, Yael Spector
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Abstract
Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.
Claims5
A method of treating a cancer associated with the p53 gene in a subject, comprising administering to a subject in need thereof an effective amount of a composition comprising a nucleic acid, wherein the nucleic acid comprises SEQ ID NO:
- 1or a sequence at least about 80% identical to SEQ ID NO:
- 1.
A method of inducing tumor cell death or inhibiting tumor cell proliferation in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a nucleic acid, wherein the nucleic acid comprises SEQ ID NO:
- 1 or a sequence at least about 80% identical to SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.