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US 9,006,203 B2Granted
Method of reducing inflammatory infiltration in subjects with inflammatory lung disease
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDennis M. Klinman, Hiroshi Yamada
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Abstract
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for reducing neutrophil infiltration in subjects with inflammatory lung disease-by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
Claims21
A method of reducing infiltration of neutrophils into a lung of a subject with an inflammatory lung disease, comprising
- administering to the subject with the inflammatory lung disease a therapeutically effective amount of a suppressive oligodeoxynucleotide, wherein the suppressive oligodeoxynucleotide comprises from 2 to 4 guanosine-rich sequences, forms a G-tetrad, is at most 100 nucleotides in length, and has a CD value of greater than about 2.9 wherein the oligodeoxynucleotide comprises the nucleic acid sequence set forth as SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 14, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, or SEQ ID NO:
- 21,
- thereby reducing the infiltration of neutrophils into the lung of the subject with the inflammatory lung disease.
8 more elements
Dependencies are inferred from the claim text.