Polymeric carrier

A polymeric carrier comprising:

• (a) a plurality of polymers that are block copolymers assembled into a polymeric carrier, the polymeric carrier comprising a core and a shell, the block copolymers having the chemical Formula I:
• wherein
• each of A0, A1, A2, A3 and A4 is —C—C—;
• Y0 is —C(O)O(1C-10C)alkyl-, optionally substituted with one or more fluorine groups;
• Y1 is —C(O)O(2C-10C)alkyl-;
• Y2 is —C(O)OCH2CH2—;
• Y3 is a covalent bond;
• Y4 is —C(O)O(CH2)3CH3;
• wherein tetravalent carbon atoms of A0-A4 that are not fully substituted with R1-R5 and Y0-Y4 are completed with an appropriate number of hydrogen atoms;
• R1 is (1C-3C)alkyl;
• each of R2, R3, and R5 is —CH3;
• R4 is —CH2CH2CH3;
• Q0 is a pyridyl disulfide residue;
• Q1 is a residue selected from the group consisting of polyoxylated alkyl, polyethylene glycol, and polypropylene glycol;
• Q2 is a dimethylamino residue;
• Q3 is a carboxyl residue;
• m is greater than 0 to less than 1.0;
• n is greater than 0 to less than 1.0, wherein m+n=1;
• p is 0.1 to 0.9;
• q is 0.1 to 0.9;
• r is 0 to 0.8 wherein p+q+r=1;
• v is 1 to 25 kDa;
• and
• w is 1 to 50 kDa;
• and
• (b) at least one polynucleotide,
• wherein the polynucleotide is not in the core of the polymeric carrier.