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AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsPeter Wipf, Jingbo Xiao, Mitchell P. Fink, Valerian Kagan, Yulia Tyurina, Anthony J. Kanai
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The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the mitochondria and (b) cargo. The cargo may be selected from a wide variety of desired cargoes which are to be delivered to the mitochondria for a specific purpose. Compositions and methods are disclosed for treating an illness that is caused or associated with cellular damage or dysfunction which is caused by excessive mitochondrial production of reaction oxygen species (ROS). Compositions which act as mitochondria-selective targeting agents using the structural signaling of the β-turn recognizable by cells as mitochondria) targeting sequences are discussed. Mitochondria and cell death by way of apoptosis is inhibited as a result of the ROS-scavenging activity, thereby increasing the survival rate of the patient.
A method for delivering a moiety to mitochondria of a patient comprising administering to a patient a mitochondria-targeting compound comprising a membrane-active fragment of gramicidin S or an E-alkene isostere thereof conjugated to a moiety, wherein the gramicidin S fragment or E-alkene isostere thereof has the sequence Leu-DPhe-Pro-Val-Orn, and wherein the moiety is a reactive-oxygen species (ROS) scavenger.
A compound comprising a membrane-active fragment of gramicidin S or an E-alkene isostere thereof conjugated to a moiety, wherein the gramicidin S fragment or E-alkene isostere thereof has the sequence Leu-DPhe-Pro-Val-Orn, and wherein the moiety is a reactive-oxygen species (ROS) scavenger.
A method for delivering a moiety to mitochondria of a patient comprising administering to a patient a mitochondria-targeting compound, represented by Formula B:
A compound comprising Formula B:
Dependencies are inferred from the claim text.