High-throughput biological screening

A high-throughput flow apparatus for use with an array of wells, the apparatus comprising:

• an array of mechanical tips each corresponding to one of the wells;
• an interface for positioning each tip within its corresponding well;
• a separate post mechanically coupled with each tip and extending beyond a distal end thereof, each post thereby being adapted to contact a floor of its corresponding well and to maintain a predetermined distance between its tip and the floor of the well, each tip driven independently of its corresponding post;
• and
• a driver associated with a tip for driving the tip around its respective separate post to impart a shear stress pattern in its corresponding well.

A high-throughput flow apparatus for use with an array of wells, the apparatus comprising:

• an array of mechanical tips each corresponding to one of the wells;
• an interface for positioning each tip within its corresponding well;
• a separate sleeve associated with each tip and extending a predetermined distance beyond a distal end thereof, each sleeve thereby being adapted to contact a floor of its corresponding well and to maintain the predetermined distance between its tip and the floor of a testing chamber, wherein the testing chamber is defined by a volume captured within an inner diameter of the sleeve, each tip rotatable within its corresponding sleeve;
• and
• a driver associated a tip for driving the tip within its respective separate sleeve to impart a shear stress pattern in its testing chamber.

A high-throughput flow apparatus for use with an array of wells, the apparatus comprising:

• an array of mechanical tips each corresponding to one of the wells;
• an interface for positioning each tip within its corresponding well;
• a separate post associated with each tip and extending a predetermined distance beyond a distal end thereof, each post thereby being adapted to contact a floor of its corresponding well and to maintain the predetermined distance between its tip and the floor of the well, each tip driven independently of its corresponding post;
• and
• a driver associated a tip for driving the tip around its respective separate post to impart a shear stress pattern in its corresponding well.