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US 9,005,981 B2Granted
Assays utilizing nicotinic acetylcholine receptor subunits
AssigneeDow AgroSciences LLC
InventorsNailah Orr, Gerald B. Watson, Gary D. Gustafson, James M. Hasler, Chaoxian Geng, Scott Chouinard, Kevin R. Cook, Vincent L. Salgado
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Abstract
The present invention is in the field of identification and characterization of novel insecticidal target sites and, in particular, relates to host cells, assays and antibodies thereto.
Claims17
A non-human transgenic organism comprising a heterologous polynucleotide that is at least 99% identical to SEQ ID NO:
- 15 that encodes a receptor subunit and results in a reduced response of the transgenic organism to a spinosyn, relative to the parental organism that does not comprise the heterologous polynucleotide that is at least 99% identical to SEQ ID NO:
- 15.
A kit for use in screening compounds for activity, the kit comprising:
- a non-human transgenic organism comprising a heterologous polynucleotide that is at least 99% identical to SEQ ID NO:
- 15 that encodes a receptor subunit and results in a reduced response of the transgenic organism to a spinosyn, relative to the parental organism that does not comprise the heterologous polynucleotide that is at least 99% identical to SEQ ID NO:
- 15.
A method for screening a compound, the method comprising:
- i) providing a non-human transgenic organism comprising a heterologous polynucleotide that is at least 99% identical to SEQ ID NO:
- 15 that encodes a receptor subunit and results in a reduced response of the transgenic organism to a spinosyn, relative to the parental organism that does not comprise the heterologous polynucleotide that is at least 99% identical to SEQ ID NO:
- 15;
- ii) administering the compound to said non-human transgenic organism of step (i);
- and
- iii) observing the effect of the compound on said non-human transgenic organism of step (ii).
3 more elements
Dependencies are inferred from the claim text.