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US 9,005,962 B2Granted
Regionalised endoderm cells and uses thereof
AssigneeThe University Court of the University of Edinburgh
InventorsGillian Mary Morrison, Joshua Mark Brickman, Ifigenia Oikonomopoulou
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Abstract
The present invention relates to the generation of anterior definitive endoderm (ADE) cells from embryonic stem cells and the differentiation of such cells to, for example, pancreatic or liver cells. The invention also relates to cell lines, cell culture methods, cells markers and the like and their potential uses in a variety of applications.
Claims6
A substantially pure cell population of isolated anterior definitive endoderm (ADE) cells derived from embryonic stem (ES) cells cultured with activin,
- wherein the ADE cells are capable of
- i) proliferating in an in vitro culture without further differentiation for at least 8 passages and/or over 2 months;
- and
- ii) maintaining the potential to differentiate into derivatives of ADE cells;
- wherein the substantially pure cell population comprises at least 40% ADE cells;
- and
- wherein said ADE cells are derived from human or mouse ES cells.
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Dependencies are inferred from the claim text.