Polynucleotides encoding IL-31 monoclonal antibodies

An isolated nucleic acid molecule encoding a monoclonal antibody that specifically binds to human IL-31, wherein the encoded monoclonal antibody comprises a heavy chain variable domain and a light chain variable domain, wherein the heavy chain variable domain and the light chain variable domain each comprises a complementarity determining region (CDR) and a framework region (FR), wherein the heavy chain variable domain complementarity determining region comprises:

• a) a CDR1 having the amino acid residues of SEQ ID NO:1;
• b) a CDR2 having the amino acid residues of SEQ ID NO:2;
• and
• c) a CDR3 having the amino acid residues of SEQ ID NO:3;
• wherein the heavy chain variable domain framework region comprises:
• d) a FR1 having at least 90% sequence identity with amino acid residues of SEQ ID NO:12;
• e) a FR2 having at least 90% sequence identity with amino acid residues of SEQ ID NO:13;
• f) a FR3 having at least 90% sequence identity with amino acid residues of SEQ ID NO:14;
• and
• g) a FR4 having at least 90% sequence identity with amino acid residues of SEQ ID NO:15;
• wherein the light chain variable domain complementarity determining region comprises:
• h) a CDR1 having the amino acid residues of SEQ ID NO:5;
• i) a CDR2 having the amino acid residues of SEQ ID NO:6;
• and
• j) a CDR3 having the amino acid residues of SEQ ID NO:7;
• and
• wherein the light chain variable domain framework region comprises:
• k) a FR5 having at least 90% sequence identity with amino acid residues of SEQ ID NO:17;
• l) a FR6 having at least 90% sequence identity with amino acid residues of SEQ ID NO:18;
• m) a FR7 having at least 90% sequence identity with amino acid residues of SEQ ID NO:19;
• and
• n) a FR8 having at least 90% sequence identity with amino acid residues of SEQ ID NO:20.