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US 9,005,912 B2Granted
Hybridoma cell line for producing antibody for type II collagen
AssigneeI-Shou University
InventorsChih-Hsin Hung, Chi-Yen Shen, Shyh-Ming Kuo, I-Fen Chen, Shih-Han Wang
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Abstract
The present invention provides a hybridoma cell line (DSM ACC3145), wherein the hybridoma cell line produces an antibody which specifically binds to an amino acid sequence of type II collagen comprising: K-G-E-P-G-D-D-G-P-S-C (as set forth in SEQ ID NO. 1); and a method for detecting osteoarthritis, by identifying a presence of type II collagen in a urine sample through containing the urine sample with the said antibody.
Claims8
A method for detecting osteoarthritis, comprising the steps of:
- identifying the presence of unwound type II collagen or fragments thereof in a urine sample by contacting the urine sample with an antibody produced by the hybridoma cell line deposited at DSMZ-Deutsche Sammlung von Mikroorganismen and Zellkulturen with deposit number DSM ACC3145;
- and
- detecting binding by the antibody, wherein the presence of unwound type II collagen or fragments thereof in the urine sample indicates osteoarthritis.
Dependencies are inferred from the claim text.