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US 9,005,620 B2Granted
Compounds
AssigneeMedImmune, LLC
InventorsSimon Charles Cruwys, Steven Godfrey Lane, Philip Mallinder
Life of this patent
Estimating the term…
Abstract
Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6) and neutralize its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating inflammatory diseases and tumors associated with IL-6.
Claims6
An isolated antibody molecule for human IL-6, comprising a set of CDRs:
- HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, in which:
- HCDR1 has amino acid sequence SEQ ID NO:
- 3;
- HCDR2 has amino acid sequence SEQ ID NO:
- 4;
- HCDR3 has amino acid sequence SEQ ID NO:
- 115;
- LCDR1 has amino acid sequence SEQ ID NO:
- 8;
- LCDR2 has amino acid sequence SEQ ID NO:
- 9;
- and
- LCDR3 has amino acid sequence SEQ ID NO:
- 120, and wherein
- the binding member has an IC50 of less than 100 pM in an assay for inhibition of proliferation of TF-1 cells in response to 20 pM human IL-6.
12 more elements
Dependencies are inferred from the claim text.