Compositions and soft tissue replacement methods

A composition comprising:

• a) an adipose tissue;
• b) a hydrogel material comprising a glycosaminoglycan polymer;
• c) a compound having the structure of formula VIII
• wherein each dashed line represents the presence or absence of a bond;
• Z2 is CH or N;
• Z5 is CH2, NH, O, or S;
• Z7 and Z8 are independently CH2, O, or S;
• R8 is H, C1-6 hydrocarbyl, or C1-6 alkyl-OH;
• R9 and R11 are independently C1-6 alkyl, OH, F, Cl, Br, I, or O;
• and
• R12 is H, OH, O, F, Cl, Br, I, C1-4 —O-alkyl, C1-4 haloalkyl, or aryl;
• a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable amine salt thereof.