Bi-functional co-polymer use for ophthalmic and other topical and local applications
AssigneeEyeon Particle Sciences LLC
InventorsEugene Rex Cooper, David Maxwell Kleinman, Andrew Loxley, Mark Mitchnick
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Abstract
The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
Claims25
A method for prolonging the stability of an ocular surface tear film of a subject, comprising contacting said ocular surface of said subject with a composition comprising a graft copolymer having a positively charged backbone and hydrophilic water soluble side chains, wherein said graft copolymer is PLL-g-PEG in an amount and for a duration so as to prolong the stability of said tear film of said subject.
A method for prolonging the stability of an ocular surface tear film of a subject, comprising contacting an ocular surface of said subject with a composition comprising a graft copolymer having a positively charged backbone and hydrophilic water soluble side chains, wherein said graft copolymer is PLL-g-PEG in an amount and for a duration so as to prolong the stability of said tear film of said subject, wherein said prolonging is measured using tear film break up time (TFBUT).
Dependencies are inferred from the claim text.