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AssigneeNew York University
InventorsRacquel Z. LeGeros, Haijing Gu, Dindo Mijares, Deepak Saxena, Sudharani Bodepudi
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The present invention provides compositions including saturated calcium phosphate (sCaP) solutions, that may be prepared from mixtures of calcium deficient apatite and one or more of sodium fluoride and zinc chloride, or F or Zn ions. The solutions may be prepared from mixtures of calcium compounds and one or more of sodium or potassium phosphates, sodium or potassium fluoride and zinc salts with, for instance, either phosphoric or hydrochloric acids. Such compositions may be useful for increasing occlusion of dentin tubules, decreasing bacterial attachment to dentin tubules, decreasing bacterial growth or colonization on tooth surfaces such as enamel and dentin surfaces including on dentin tubules, increasing resistance to acid dissolution, inhibiting dental caries formation and progression and tooth decay and inhibiting development of tooth hypersensitivity.
A method for increasing or promoting occlusion of dentin tubules on the surface of a tooth comprising providing a composition including a saturated calcium phosphate (sCaP) solution supersaturated with both F- and Zn-substituted calcium phosphates and having a pH of about 5.0 to 7.5.
A method for decreasing bacterial attachment to dentin tubules or decreasing bacterial attachment to the surface of a tooth comprising providing a composition including a saturated calcium phosphate (sCaP) solution supersaturated with both F- and Zn-substituted calcium phosphates and having a pH of about 5.0 to 7.5.
A method for decreasing bacterial growth or colonization on the surface of a tooth comprising providing a composition including a saturated calcium phosphate (sCaP) solution supersaturated with both F- and Zn-substituted calcium phosphates and having a pH of about 5.0 to 7.5.
A method for inhibiting tooth decay or inhibiting development of tooth hypersensitivity comprising providing a composition including a saturated calcium phosphate (sCaP) solution supersaturated with both F- and Zn-substituted calcium phosphates and having a pH of about 5.0 to 7.5.
A method for inhibiting acid dissolution of a tooth surface comprising providing a composition including a saturated calcium phosphate (sCaP) solution supersaturated with both F- and Zn-substituted calcium phosphates and having a pH of about 5.0 to 7.5.
A composition that may be useful for one or more of increasing occlusion of dentin tubules, decreasing bacterial attachment to dentin tubules, decreasing bacterial growth or colonization on tooth surfaces including on dentin tubules, inhibiting tooth decay or inhibiting development of tooth hypersensitivity comprising a saturated calcium phosphate (sCaP) solution supersaturated with both F- and Zn-substituted calcium phosphates and having a pH of about 5.0 to 7.5.
Dependencies are inferred from the claim text.