Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders

A compound, or a pharmaceutically acceptable salt thereof, represented by formula II:

• wherein, independently for each occurrence,
• L is —C(═O)R3, —C(═O)[C(R1)2]pR3, —C(═O)[C(R1)2]pC(═O)R3, —[C(R1)2]pC(═O)R3, —C(═O)[C1-10alkylene]R3, —[C1-10alkylene]C(═O)R3 or —C(═O)[C1-10alkylene]C(═O)R3;
• R1 is hydrogen, halo, azido, alkyl, haloalkyl, perhaloalkyl, fluoroalkyl, perfluoroalkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, amino, alkylamino, arylamino, acylamino, heteroarylamino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, acyl, carboxyl, oxycarbonyl, acyloxy, silyl, thioether, sulfo, sulfonate, sulfonyl, sulfonamido, formyl, cyano, or isocyano;
• R4 is hydrogen, halo, azido, alkyl, haloalkyl, perhaloalkyl, fluoroalkyl, perfluoroalkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, amino, alkylamino, arylamino, acylamino, heteroarylamino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, acyl, carboxyl, oxycarbonyl, acyloxy, silyl, thioether, sulfo, sulfonate, sulfonyl, sulfonamido, formyl, cyano, isocyano, —OR5, —SR5, —N(R5)2, or —(C(R1)2)qC(R1)3;
• R5 is hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, or —(C(R1)2)qC(R1)3;
• R7 is halo, hydroxy, alkoxy, aralkyloxy, heteroaralkyloxy, acyl, or acyloxy;
• p is 1-10 inclusive;
• and
• q is 0-10 inclusive.