Neuromodulation methods using balloon catheter
AssigneeMetavention, Inc.
InventorsBobak Robert Azamian, Jonathan Allen Coe, Scott Bradley Vafai
Life of this patent
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Abstract
According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.
Claims20
A method of facilitating modulation of nerves surrounding a hepatic artery of a subject, comprising:
- inserting a balloon catheter into a vasculature of a subject,
- wherein the balloon catheter comprises a balloon having at least one electrode positioned on an external surface of the balloon;
- advancing a distal section of the balloon catheter to a location within a portion of a hepatic artery of the vasculature;
- at least partially occluding the portion of the hepatic artery using the balloon catheter,
- causing the at least one electrode to contact a wall of the portion of the hepatic artery at a target site;
- denervating the portion of the hepatic artery at the target site using the balloon catheter sufficient to reduce a blood glucose level of the subject;
- and
- removing the balloon catheter from the vasculature of the subject.
A method of facilitating modulation of nerves surrounding a hepatic artery of a subject comprising:
- inserting a balloon catheter into a vasculature of a subject,
- wherein the balloon catheter comprises a catheter body and a distal balloon having at least one electrode positioned on an external surface of the balloon;
- advancing a distal section of the balloon catheter to a location within a portion of a hepatic artery of the vasculature;
- at least partially occluding the portion of the hepatic artery using the balloon catheter,
- causing the at least one electrode to contact a wall of the portion of the hepatic artery at a target treatment site;
- modulating one or more nerves that innervate at least one of a liver or a pancreas of the subject at the target treatment site using the balloon catheter sufficient to reduce a blood glucose level of the subject;
- and
- removing the balloon catheter from the vasculature of the subject.
A method of facilitating modulation of nerves surrounding a hepatic artery of a subject comprising:
- providing an energy delivery device comprising an expandable balloon having at least one electrode, the energy delivery device configured for:
- intravascularly accessing a portion of a hepatic artery;
- causing the at least one electrode of the expandable balloon to contact a wall of the hepatic artery;
- and
- delivering energy through the wall of the hepatic artery sufficient to denervate one or more sympathetic nerves associated with a liver.
Dependencies are inferred from the claim text.