Treatment of non-alcoholic fatty liver disease
AssigneeMetavention, Inc.
InventorsBobak Robert Azamian, Jonathan Allen Coe, Scott Bradley Vafai
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Abstract
According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.
Claims20
A method of treating non-alcoholic fatty liver disease, comprising:
- positioning a distal portion of an energy delivery device within a common hepatic artery of a subject;
- at least partially blocking one or more sympathetic nerves that innervate a liver using the energy delivery device by intravascularly delivering energy through a wall of the common hepatic artery at a target location sufficient to treat non-alcoholic fatty liver disease;
- and
- removing the energy delivery device from the subject,
- wherein the energy delivery device is configured to contact the wall of a portion of the common hepatic artery at the target location while the energy is being delivered.
A method of treating non-alcoholic fatty liver disease, comprising:
- positioning a distal end of a neuromodulation device within a hepatic artery segment of a subject;
- modulating one or more nerves that innervate a liver using the neuromodulation device sufficient to treat non-alcoholic fatty liver disease;
- and
- removing the neuromodulation device from the subject,
- wherein at least a portion of the distal end of the neuromodulation device is configured to contact a wall of the hepatic artery segment at a target location while the one or more nerves are being modulated.
A method of treating non-alcoholic fatty liver disease, comprising:
- providing an energy delivery catheter configured for:
- accessing a portion of vasculature in the vicinity of a hepatic plexus of a subject;
- and
- delivering energy through a wall of the vasculature sufficient to modulate one or more nerves of the hepatic plexus,
- wherein modulation of the one or more nerves effects treatment of non-alcoholic fatty liver disease.
Dependencies are inferred from the claim text.