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US 9,005,185 B2Granted
Nanochanneled device and related methods
AssigneesBoard of Regents, The University of Texas System, The Ohio State University Research Foundation
InventorsMauro Ferrari, Xuewu Liu, Alessandro Grattoni, Randy Goodall, Lee Hudson
Life of this patent
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Abstract
A capsule configured for in vivo refilling of a therapeutic agent. In certain embodiments, the capsule may contain methotrexate.
Claims14
An apparatus comprising:
- a capsule comprising molecules of a therapeutic agent;
- and
- a nanochannel delivery device configured to control a diffusion rate of the molecules of the therapeutic agent from the capsule, wherein:
- the capsule is configured to allow in vivo injection of the therapeutic agent into the capsule when the capsule is implanted in a patient;
- and
- the capsule is configured to allow in vivo withdrawal of the therapeutic agent from the capsule when the capsule is implanted in a patient, wherein:
- the capsule comprises a first port in fluid communication with a second port;
- the first port is configured such that a first needle can be inserted into the first port to inject the therapeutic agent into the capsule;
- and
- the second port is configured such that a second needle can be inserted into the second port to withdraw the therapeutic agent from the capsule.
7 more elements
A method of in vivo refilling of a therapeutic agent contained in a capsule, the method comprising:
- accessing the capsule in vivo with a first lumen and a second lumen, wherein the first lumen is in fluid communication with the second lumen;
- injecting the therapeutic agent into the capsule through the first lumen inserted through a patient's skin wherein a diffusion rate of the molecules of the therapeutic agent is controlled by a nanochannel delivery device;
- and
- extracting the therapeutic agent from the capsule through the second lumen inserted through a patient's skin, wherein extracting the therapeutic agent from the capsule through the second lumen and injecting the therapeutic agent into the capsule through the first lumen are performed at the same time.
1 more element
Dependencies are inferred from the claim text.