Oxidized thiophospholipid compounds and uses thereof

A compound having formula III:

• wherein:
• each of A1 and A2 is independently selected from the group consisting of CR″R′″, C═O and C═S;
• each of B′ and B″ is independently selected from the group consisting of sulfur and oxygen;
• each of D′ and D″ is independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, phosphonate and thiophosphonate;
• and
• each of X1 and X2 is independently a saturated or unsaturated hydrocarbon having the general formula II:
• wherein:
• m is an integer of 3-26;
• and
• Z is selected from the group consisting of:
• wherein:
• W is selected from the group consisting of oxygen, sulfur, nitrogen and phosphorus, whereby each of said nitrogen and phosphorus is substituted by at least one substituent selected from the group consisting of hydrogen, lone pair electrons, alkyl, halo, cycloalkyl, aryl, hydroxy, thiohydroxy, alkoxy, aryloxy, thioaryloxy, thioalkoxy and oxo;
• R′ is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and heteroaryl;
• and
• at least one Z is not hydrogen;
• and wherein:
• each of R″ and R′″ and each of Ra, R′a, Rb, R′b, to Rm−1, R′m−1, Rm and R′m is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkylnyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, halo, trihalomethyl, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, phosphonate, thiophosphonate, phosphate, thiophosphate, phosphinyl, sulfonyl, sulfinyl, sulfonamide, amide, carbonyl, thiocarbonyl, C-carboxy, O-carboxy, O-carbamate, N-carbamate, C-thiocarboxy, S-thiocarboxy and amino, or, alternatively, at least two of Ra, R′a, Rb, R′b, to Rm−1, R′m−1, Rm and R′m form at least one four-, five- or six-membered aromatic, heteroaromatic, alicyclic or heteroalicyclic ring,
• or a pharmaceutically acceptable salt, a hydrate or a solvate thereof.