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US 8,999,937 B2Granted
Glucocorticoid induced leucine zipper mimetics as therapeutic agents in multiple sclerosis
AssigneeIndiana University Research and Technology Corporation
InventorMythily Srinivasan
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Abstract
Polypeptide compositions that mimic the activity of glucocorticoid induced leucine zipper (GILZ) on the immune system are described. Also described is a method of treating multiple sclerosis using compositions comprising GILZ or lower molecular weight polypeptides with structural relationships to GILZ.
Claims10
A pharmaceutical composition comprising a polypeptide from 6 to 35 amino acid residues, the polypeptide comprising 1 to 3 tetrapeptides having the sequence of PXXP, wherein
- P is proline;
- and
- X is any amino acid, and
- wherein the polypeptide comprises the amino acid sequence of CLSPEEPAPESPQVPEAPGGSAV (SEQ ID NO:
- 6),
- and wherein the pharmaceutical composition further comprises a cell penetrating peptide, wherein the polypeptide and the cell penetrating peptide form a complex.
3 more elements
Dependencies are inferred from the claim text.