Increase of myeloid microvesicles in the cerebrospinal fluid as biomarker of microglia/macrophage activation in neurological disorders
AssigneesConsiglio Nazionale Delle Ricerche, Universita' Degli Studi Di Milano, Ospedale San Raffaele S.R.L.
InventorsClaudia Verderio, Michela Matteoli, Roberto Furlan
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Abstract
The present invention relates to a method for the diagnostic and/or prognostic of a neurological disease characterized by an inflammation process in a subject comprising measuring the amount of myeloid derived microvesicles in a cerebrospinal fluid sample obtained from the subject. The invention further relates to a method for predicting and/or monitoring the efficacy of a treatment for a neurological pathology or for monitoring a neurological disease progression.
Claims12
A method for diagnosing and/or monitoring of a neurological disease characterized by an inflammatory process wherein the neurological disease and/or the inflammatory process is characterized by microglial activation in a subject, the method comprising
- (a) labeling microglia/macrophage derived microvesicles with IB-4, wherein the microvesicles are present in a cerebrospinal fluid sample obtained from the subject;
- (b) measuring the amount of said labelled myeloid microglia/macrophage derived microvesicles in said sample obtained from the subject,
- wherein if the measured amount is above a control value, the subject is affected by a neurological disease characterized by an inflammatory process.
A method for predicting and/or monitoring the efficacy of a treatment or progression of a neurological disease, wherein the neurological disease is characterized by an inflammatory process in a subject, comprising:
- (a) labeling microglia/macrophage derived microvesicles with IB-4, wherein the microvesicles are present in a cerebrospinal fluid sample obtained from the subject,
- (b) measuring the amount of the labeled microglia/macrophage derived microvesicles in a cerebrospinal fluid sample obtained from the subject, and
- (c) comparing the measured amount to a control value.
Dependencies are inferred from the claim text.