Porous biomaterial on hydroxyapatite
AssigneeApaTech Limited
InventorsThomas Buckland, Charles Campion
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Abstract
The present invention provides a synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 23% by volume or greater, wherein the surface free energy of the biomaterial is 19 mJ/m.
Claims16
A synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 25-35% by volume, wherein the surface free energy of the biomaterial is 30 mJ/m2 or greater, and wherein micro-pores resulting in the microporosity have an interconnection diameter of 50 nm to 10 μm as measured by mercury porosimetry analysis, wherein the mean interconnected diameter of micro-pores resulting in the microporosity is 0.5 μm to 10 μm.
A silicon-containing sintered calcium phosphate biomaterial having a microporosity of 25-35% by volume and a surface free energy of 30 mJ/m2 or greater, wherein micro-pores resulting in the microporosity have an interconnection diameter of 50 nm to 10 μm as measured by mercury porosimetry analysis, wherein the mean interconnected diameter of micro-pores resulting in the microporosity is 0.5 μm to 10 μm.
A synthetic silicon-substituted calcium phosphate biomaterial having a microporosity of 25-35% by volume and a surface free energy of 30 mJ/m2 or greater, wherein the biomaterial comprises substantially no impurity phases of calcium oxide and/or tricalcium phosphate, wherein micropores resulting in the microporosity have an interconnection diameter of 50 nm to 10 μm as measured by mercury porosimetry analysis, wherein the mean interconnected diameter of micropores resulting in the microporosity is 0.5 μm to 10 μm.
A method of selecting a synthetic porous osteoinductive biomaterial and providing osteoinduction of bone to treat a patient or animal, the method comprising:
- (a) selecting an osteoinductive synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 25-35% by volume, a surface free energy of 30 mJ/m2 or greater and micropores resulting in the microporosity have an interconnection diameter of 50 nm to 10 μm as measured by mercury porosimetry analysis, wherein the mean interconnected diameter of micropores resulting in the microporosity is 0.5 μm to 10 μm;
- (b) configuring said osteoinductive biomaterial as a replacement bone-material to provide for osteoinduction;
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- (c) implanting said osteoinductive biomaterial in the patient or animal.
Dependencies are inferred from the claim text.