Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents

A multi-component, absorbable, fiber-reinforced, radiopaque, tubular stent for a urinogenital conduit comprising:

• i) a central coil comprising an absorbable radiopaque hybrid composition comprising radiopaque particles dispersed in a crystalline polyaxial copolyester, the copolyester derived from glycolide and at least one additional monomer selected from the group consisting of 1-lactide, trimethylene carbonate, ε-caprolactone, p-dioxanone, 1,5-dioxepan-2-one, and a morpholinedione;
• ii) a tubular knitted mesh disposed on one surface of the central coil, the coil and the knitted mesh together forming a knitted core, the knitted mesh comprising an absorbable polymeric multifilament yarn comprising a crystalline polyaxial copolyester, the copolyester derived from glycolide and at least one additional monomer selected from the group consisting of 1-lactide, trimethylene carbonate, ε-caprolactone, p-dioxanone, 1,5-dioxepan-2-one, and a morpholinedione;
• iii) a composite matrix, the matrix being of a composition comprising an absorbable polyaxial copolyester and a hydrophilic polymer additive, the copolyester derived from 1-lactide and at least one additional monomer selected from the group consisting of glycolide, trimethylene carbonate, ε-caprolactone, p-dioxanone, 1,5-dioxepan-2-one, and a morpholinedione, said composite matrix reinforced with and impregnating the knitted core such that the composite matrix forms a tube,
• wherein the hydrophilic polymeric additive has a molecular weight of 1 to 70 kDa, the hydrophilic polymeric additive selected from the group consisting of polyethylene glycol, and polyethylene glycol end-grafted with at least one monomer selected from the group consisting of 1-lactide, glycolide, trimethylene carbonate, e-caprolactone, p-dioxanone, 1,5-dioxepan-2-one and a morpholinedione,
• wherein the matrix and knitted core alone are capable of maintaining patency of a urinogenital conduit.