Computationally optimized broadly reactive antigens for influenza
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsTed M. Ross, Brendan M. Giles
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Abstract
Described herein is the development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates. The optimized HA protein was developed through a series of HA protein alignments, and subsequent generation of consensus sequences, for clade 2 H5N1 influenza virus isolates. The final consensus HA amino acid sequence was reverse translated and optimized for expression in mammalian cells. Influenza virus-like particles containing the optimized HA protein are an effective vaccine against H5N1 influenza virus infection in animals.
Claims13
An isolated nucleic acid molecule comprising a nucleotide sequence encoding an influenza hemagglutinin (HA) polypeptide, wherein the nucleotide sequence encoding the HA polypeptide is at least 96% identical to SEQ ID NO:
- 1.
An isolated influenza HA polypeptide, wherein the amino acid sequence of the polypeptide is at least 99% identical to SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.