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US 8,796,212 B2Granted
Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis
AssigneeBioSurface Engineering Technologies, Inc.
InventorsPaul O. Zamora, Brent Lee Atkinson, Xinhua Lin, Louis A. Pena
Life of this patent
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Abstract
A composition comprising a synthetic growth factor analog comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analog is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
Claims14
A compound of formula II
- wherein:
- X is SEQ ID NO:
- 7;
- R1 is hydrogen (H—), such that the terminal group is —NH2;
- R6 is a lysine;
- R5 is a lysine;
- R4 is —NH2 at the carboxyl terminal group;
- Y is Ahx-Ahx-Ahx wherein Ahx is 6-aminohexanoic acid;
- and
- Z is SEQ ID NO:
- 5.
8 more elements
A composition comprising:
- a compound of formula II
- wherein:
- X is SEQ ID NO:
- 7;
- R1 is hydrogen (H—), such that the terminal group is —NH2;
- R6 is a lysine;
- R5 is a lysine;
- R4 is —NH2 at the carboxyl terminal group;
- Y is Ahx-Ahx-Ahx wherein Ahx is 6-aminohexanoic acid;
- Z is SEQ ID NO:
- 5;
- and
- an osteoconductive material comprising one or more of an inorganic material, a synthetic polymer, a natural polymer, or an allograft bone,
- wherein the compound of formula II is attached to and can be released from the osteoconductive material.
11 more elements
A kit comprising:
- a lyophilized vial of, with or without excipients, a compound of formula II
- wherein:
- X is SEQ ID NO:
- 7;
- R1 is hydrogen (H—), such that the terminal group is —NH2;
- R6 is a lysine;
- R5 is a lysine;
- R4 is —NH2 at the carboxyl terminal group;
- Y is Ahx-Ahx-Ahx wherein Ahx is 6-aminohexanoic acid;
- Z is SEQ ID NO:
- 5;
- and
- a container of osteoconductive material.
10 more elements
A method for treating a bone lesion comprising:
- coating an osteoconductive material with a compound of formula II having the following structure
- wherein:
- X is SEQ ID NO:
- 7;
- R1 is hydrogen (H—), such that the terminal group is —NH2;
- R6 is a lysine;
- R5 is a lysine;
- R4 is —NH2 at the carboxyl terminal group;
- Y is Ahx-Ahx-Ahx wherein Ahx is 6-aminohexanoic acid;
- and
- Z is SEQ ID NO:
- 5,
- to generate a coated osteoconductive material with the compound of formula II releasably attached thereto;
- and
- implanting the coated osteoconductive material in the bone lesion;
- wherein the osteoconductive material comprising one or more of an inorganic material, a synthetic polymer, or an allograft bone.
13 more elements
A method for treating a bone lesion comprising:
- administering to a vertebrate subject in need of such treatment an effective amount of a compound of formula II
- wherein:
- X is SEQ ID NO:
- 7;
- R1 is hydrogen (H—), such that the terminal group is —NH2;
- R6 is a lysine;
- R5 is a lysine;
- R4 is —NH2 at the carboxyl terminal group;
- Y is Ahx-Ahx-Ahx wherein Ahx is 6-aminohexanoic acid;
- and
- Z is SEQ ID NO:
- 5.
9 more elements
Dependencies are inferred from the claim text.