Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject

A system comprising:

• an apparatus comprising an energy generator configured to provide at least one energy stimulus to one or more nervous system components at a first location on a vertebrate subject, and a device configured to deliver one or more immunogen at a second location on the vertebrate subject.

A method for vaccinating a vertebrate subject against a disease comprising:

• providing at least one energy stimulus from one or more transducers, wherein the at least one energy stimulus is configured to modulate one or more nervous system components in a tissue of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are configured to provide in a combination and in a temporal sequence sufficient to accelerate, prolong, facilitate, or alter in form or type the immune response to the one or more immunogen in the vertebrate subject.

A system for enhancing an immune response in a vertebrate subject comprising:

• circuitry for an energy generator providing at least one energy stimulus configured to modulate one or more nervous system components at a first location on a vertebrate subject, and circuitry for an apparatus configured to deliver one or more immunogen at a second location on the vertebrate subject.