US 8,788,021 B1Granted

Live being optical analysis system and approach

AssigneeThe Board of Trustees of the Leland Stanford Junior Univerity

InventorsBenjamin A. Flusberg, Eric David Cocker, Juergen Claus Jung, Mark Jacob Schnitzer

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Abstract

Analysis of live beings is facilitated. According to an example embodiment of the present invention, a light-directing arrangement such as an endoscope is mounted to a live being. Optics in the light-directing arrangement are implemented to pass source light (e.g., laser excitation light) into the live being, and to pass light from the live being for detection thereof. The light from the live being may include, for example, photons emitted in response to the laser excitation light (i.e., fluoresced). The detected light is then used to detect a characteristic of the live being.

Claims33

Dependent claims

A method for in vivo analysis of a freely-moving live being, the method comprising;

a) fixing a housing to the live being, wherein the housing encloses therein a light-directing arrangement, wherein the light-directing arrangement comprises a light source to provide stimulation light, and wherein a combined weight of the housing and the light-directing arrangement comprising the light source is less than 4 grams;
b) passing stimulation light through the light-directing arrangement;
c) using the light-directing arrangement, providing the stimulation light to a target portion of the freely-moving live being while the freely-moving live being moves about, wherein said stimulation light induces response light from said target portion;
d) passing the response light from the target portion to a light detector;
e) at the light detector, receiving and detecting the response light, and generating a signal corresponding to the detected light;
and
f) generating a cellular resolution image of said target portion using said signal.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 11/338,598Filed 24 Jan 2006 · us provisional application
Priority: 24 Jan 2005
Granted: 22 Jul 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification23 codes

A61B 5/0068
Arrangements for scanning: confocal scanning
A61B 5/0013
Characterised by the type of physiological signal transmitted: medical image data
A61B 5/0059
Measuring for diagnostic purposes ; Identification of persons: using light, e.g. diagnosis by transillumination, diascopy, fluorescence
A61B 5/0062
Using light, e.g. diagnosis by transillumination, diascopy, fluorescence: arrangements for scanning

Family

Application60/646,858Us provisional application · filed 24 Jan 2005
Application60/646,711Us provisional application · filed 24 Jan 2005
US 8,788,021 B1This patent

From the US filing history. Foreign family members aren’t listed.

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