System and method of iterative image reconstruction for computed tomography

A method comprising:

• acquiring a set of projection data corresponding to a plurality of image voxels of a set of CT image data, wherein each of the plurality of image voxels corresponds to a distinct time of data acquisition;
• selecting a kinetic parameter model to estimate a plurality of sets of kinetic parameters for the plurality of image voxels, each set of kinetic parameters representing a motion of an object at the distinct time of data acquisition of the associated image voxel;
• calculating motion of the plurality of image voxels using the kinetic parameter model;
• and
• reconstructing an image of the object based on the calculated motion;
• and
• wherein the kinetic parameter model estimates the plurality of sets of kinetic parameters for the plurality of image voxels independently from the set of projection data.

An imaging system comprising:

• a rotatable gantry having an opening for receiving an object to be scanned;
• an x-ray source coupled to the rotatable gantry and configured to project x-rays through the opening;
• a generator configured to energize the x-ray source to an energy level to generate x-rays corresponding to the energy level;
• a detector having pixels therein, the detector attached to the rotatable gantry and positioned to receive x-rays projected from the x-ray source;
• and
• a computer programmed to:
• access a CT projection dataset corresponding to a plurality of image voxels acquired over a period of data acquisition;
• model a plurality of kinetic parameters corresponding to the plurality of image voxels, the model representing motion of the plurality of image voxels;
• calculate a motion of the object from the model;
• and
• iteratively reconstruct an image from the CT projection dataset based on the calculated motion.