Methods for producing genetically modified animals using hypermethylated transposons

A method of making a nonhuman transgenic animal whose genome comprises a hypermethylated transposon construct comprising

• hypermethylating a transposon, introducing the hypermethylated transposon comprising a transcriptional unit comprising a regulatory region operably linked to an interfering RNA (RNAi) encoding nucleic acid into a nonhuman animal egg, said transposon being inserted into a genome of the egg, and
• allowing the egg to develop in a recipient female to produce the nonhuman transgenic animal, wherein the nonhuman animal expresses the RNAi sequence.