Genetically modified non-human mammals and cells
AssigneeUniversity of Leicester
InventorsTeizo Fujita, Hans-Wilhelm Schwaeble, Cordula Margaret Stover
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Abstract
Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein MAp19; such mammals may also lack MASP-2.
Claims7
A transgenic rodent or transgenic rodent cell, wherein the gene encoding endogenous MASP-2 polypeptide and/or the gene encoding endogenous MAp19 polypeptide is/are absent or partially absent or disrupted in said rodent or said rodent cell, so that endogenous MASP-2 polypeptide and/or endogenous MAp19 polypeptide is not produced, wherein the transgenic rodent lacks a lectin complement pathway response and retains a classical complement pathway response.
Dependencies are inferred from the claim text.