Thioamide compound, method for producing thioamide compound, method for producing [(4R,6R)-6-aminoethyl-1,3-dioxan-4-yl]acetate derivative, and method for producing atorvastatin

A method for producing a thioamide compound represented by the following general formula (1), the method comprising:

• reacting a compound represented by the following general formula (2) with a compound represented by the following general formula (3) to obtain the thioamide compound represented by the following general formula (1):
• wherein, in the general formula (1), R1 represents one of —OR11 and —NR12R13;
• R2 and R3 each independently represent one of a protecting group of an amide group and a hydrogen atom;
• the R11 represents one of a protecting group of a hydroxyl group and a hydrogen atom;
• and the R12 and R13 each independently represent one of a protecting group of an amino group and a hydrogen atom, where the R12 and R13 may together form a protecting group having a cyclic structure,
• wherein, in the general formula (2), R1 represents one of —OR11 and —NR12R13;
• the R11 represents one of a protecting group of a hydroxyl group and a hydrogen atom;
• the R12 and R13 each independently represent one of a hydrogen atom and a protecting group of an amino group, where the R12 and R13 may together form a protecting group having a cyclic structure;
• and in the general formula (3), R2 and R3 each independently represent one of a protecting group of an amide group and a hydrogen atom.

A method for producing atorvastatin, comprising:

• converting a thioamide compound represented by the following general formula (1) into an acetate derivative represented by the following general formula (4) and converting the acetate derivative represented by the following general formula (4) into atorvastatin:
• wherein, in the general formula (1), R1 represents one of —OR11 and —NR12R13;
• R2 and R3 each independently represent one of a protecting group of an amide group and a hydrogen atom;
• the R11 represents one of a protecting group of a hydroxyl group and a hydrogen atom;
• and the R12 and R13 each independently represent one of a protecting group of an amino group and a hydrogen atom, where the R12 and R13 may together form a protecting group having a cyclic structure, and
• wherein, in the general formula (4), R4 represents one of a protecting group of a carboxyl group and a hydrogen atom;
• and R5 and R6 each independently represent one of a hydrocarbon group having 1 to 6 carbon atoms and a hydrogen atom, where the R5 and R6 may together form a cyclic structure.