US 8,785,663 B2 · Polymorphic forms of Lubiprostone

Abstract

There is provided a crystalline form of Lubiprostone, termed APO-II and methods for making APO-II. APO-II is a polymorphic form of Lubiprostone.

Claims20

Dependent claims

A crystalline form of Lubiprostone having an X-ray powder diffraction pattern acquired using CuKα radiation comprising peaks, in terms of 2-theta, at approximately 8.98, 13.53, 18.06 and 22.74.

Dependencies are inferred from the claim text.

Facts

Application

13/575,680Filed 28 Jan 2011 · us provisional application

Priority

28 Jan 2010

Published

US 2013/0096325 A118 Apr 2013

Granted

22 Jul 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 311/94
Ortho- or peri-condensed with carbocyclic rings or ring systems: condensed with rings other than six-membered or with ring systems containing such…
A61K 31/558
Eicosanoids, e.g. leukotrienes or prostaglandins: having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
A61P 1/10
Drugs for disorders of the alimentary tract or the digestive system: laxatives
C07C 405/00
Compounds containing a five-membered ring having two side-chains in ortho position to

Abstract

There is provided a crystalline form of Lubiprostone, termed APO-II and methods for making APO-II. APO-II is a polymorphic form of Lubiprostone.

Claims20

Dependent claims

A crystalline form of Lubiprostone having an X-ray powder diffraction pattern acquired using CuKα radiation comprising peaks, in terms of 2-theta, at approximately 8.98, 13.53, 18.06 and 22.74.

Dependencies are inferred from the claim text.

Polymorphic forms of Lubiprostone

Life of this patent

Abstract

Claims20

Polymorphic forms of Lubiprostone

Life of this patent

Abstract

Claims20