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AssigneeJanssen Biotech, Inc.
InventorsJuan Carlos Almagro, Patrick Branigan, Colleen Kane, William Strohl, Susann Taudte, Mark Tornetta, John Wheeler
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The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
An isolated target binding member that binds IL-25, wherein the target binding comprises an antibody light chain variable region (VL) domain comprising a CDR1 having the amino acid sequence SASQGISNYLN (SEQ ID NO:6) and a CDR2 having the amino acid sequence YTSSLHS (SEQ ID NO:7) and a CDR3 having the amino acid sequence QQYLAFPYTF (SEQ ID NO:8) and an antibody heavy chain variable region (VH) domain comprising a CDR1 having the amino acid sequence GYTMN (SEQ ID NO:10), a CDR2having the amino acid sequence LINPYNGGTSYNQNFKG (SEQ ID NO:11) and a CDR3 having the amino acid sequence EDYDGYLYFAMDY (SEQ ID NO:12).
Dependencies are inferred from the claim text.