T cell receptors and related materials and methods of use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsSteven A. Rosenberg, Richard A. Morgan, Timothy L. Frankel, Peter Peng
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Abstract
The invention provides T cell receptors (TCRs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
Claims14
A T cell receptor (TCR) comprising the amino acid sequences of SEQ ID NO:
- 1-6 and 18-19.
An isolated or purified TCR comprising the amino acid sequences of SEQ ID NO:
- 7 and 8 and SEQ ID No:
- 18 and 19.
An isolated or purified protein, comprising a first polypeptide chain comprising the amino acid sequences of SEQ ID NO:
- 7 and 18, and a second polypeptide chain comprising the amino acid sequences of SEQ ID NO:
- 8 and 19.
Dependencies are inferred from the claim text.