Anti-cancer tamoxifen-melatonin hybrid ligand
AssigneeDuquesne University of the Holy Spirit
InventorsPaula A. Witt-Enderby, Vicki L. Davis, David Lapinsky
Life of this patent
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Abstract
A particularly constructed tamoxifen-melatonin hybrid ligand gives new and unexpectedly improved results in the prevention and treatment of cancer, particularly breast cancer. The hybrid ligand comprises either tamoxifen or 4-hydroxytamoxifen and also melatonin, with the tamoxifen or 4-hydroxytamoxifen and melatonin's being linked by an unsubstituted C2-C6 alkyl linker between the tamoxifen amine and the carbonyl of melatonin.
Claims5
A pharmaceutically active agent consisting essentially of a hybrid ligand of tamoxifen and melatonin linked by a 2-6 carbon alkyl linker conjoining said tamoxifen and said melatonin via a covalent linkage between an amino moiety of said tamoxifen and a hydroxylamino moiety of said melatonin.
A pharmaceutical formulation consisting essentially of a hybrid ligand of tamoxifen and melatonin linked by a 2-6 carbon unsubstituted alkyl linker conjoining said tamoxifen and said melatonin via a covalent linkage of an amino moiety of said tamoxifen and a hydroxylamino moiety of said melatonin, and at least one pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.