Calcium sensing receptor modulating compounds and pharmaceutical use thereof

A compound according to formula I

• wherein
• A represents C6-10aryl, C1-9heterocycloalkylphenyl, C1-9heteroaryl or C3-7cycloalkyl, wherein said C6-10aryl, C1-9heterocycloalkylphenyl, C1-9heteroaryl or C3-7cycloalkyl is optionally further substituted with one or more, same or different substituents represented by halogen, hydroxy, mercapto, trifluoromethyl, cyano, carboxy, —C(O)H, —NH2, —C(O)NH2, nitro, oxo, —S(O)2NH2, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, C1-6alkoxy, C1-4alkoxycarbonyl, C1-4alkylcarbonyloxy, C1-4alkoxycarbonyloxy, C1-4alkoxysulfonyloxy, C1-4alkoxycarbamoyl, C1-4aminocarbonyl, C1-4alkylthio, C3-7cycloalkyl, C3-7cycloalkenyl, C1-6amino, iminomethyl, C1-4aminosulfonyl, C1-4aminocarbonyloxy, C1-4alkylsulfonylamino, hydroxyiminomethyl, C1-4alkylcarbonylamino, C1-4alkylsulfonyl, C1-6 heterocycloalkyl, C2-6heterocycloalkenyl, C1-5heteroaryl or phenyl;
• R1 represents one or more, same or different substituents selected from halogen, cyano, —NH2, carboxy, C1-6-amino, hydroxy, mercapto, —C(O)H, —C(O)NH2, nitro, oxo, hydroxymethyl, C1-6alkoxy, carboxyC1-4alkoxy, C1-6alkoxycarbonyl, C1-6alkoxycarbonylC1-6 alkoxy, carboxyC1-4alkyl, C1-6alkoxycarbonylC1-4alkyl, C1-6alkylcarbonyl, C1-6aminocarbonyl, hydroxyaminocarbonyl, C3-6cycloalkylaminocarbonyl, C1-6heterocycloalkylaminocarbonyl, C3-6cycloalkylamino, C1-6 heterocycloalkylcarbonyl, C6-14aryl, C1-9heteroaryl, C1-6heteroarylaminocarbonyl, —S(O)2NH2, C1-6ureido, C1-6thioureido, C1-4alkylcarbonyloxy, C1-4alkoxycarbonyloxy, C1-4alkoxysulfonyloxy, C1-6heterocycloalkyloxy, C1-6alkylthio, C1-6aminosulfonyl, C1-6aminocarbonyloxy, C1-6alkylsulfonylamino, C1-6alkylsulfonylaminoC1-3 alkyl, C6-10 arylamino, C6-10arylaminocarbonyl, C6-10aryloxycarbonyl, C1-4alkoxycarbamoyl, C6-10arylcarbonylamino, C6-10arylsulfonylamino, C1-6alkylcarbonylamino, C1-3 alkylcarbonylaminoalkyl, C2-6alkenylcarbonylamino, C3-6cycloalkenylcarbonylamino, C3-6 cycloalkylcarbonylamino, C1-4alkoxycarbonylamino, C1-6heterocycloalkylcarbonylamino, C1-6alkylsulfonyl, C1-6hetero cycloalkylsulfonyl or C1-4 alkylsulfonylamino carbonyl, iminomethyl, hydroxyiminomethyl, amidino, trifluoromethyl, C1-6alkyl, C2-4alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, aminoC1-6alkyl, C1-6 haloalkyl, C3-7 cycloalkyl, C3-7cycloalkenyl, C1-6 heterocycloalkyl, C2-6heterocycloalkenyl, methoxycarbonylC1-3 alkyl or carboxyC6-10aryl, wherein said C1-6amino, C1-6alkoxy, carboxyC1-4alkoxy, C1-6alkoxycarbonyl, C1-6alkylcarbonyl, C1-6aminocarbonyl, C3-6cycloalkylaminocarbonyl, C1-6 heterocycloalkylaminocarbonyl, C3-6cycloalkylamino, C1-6 heterocycloalkylcarbonyl, C6-14aryl, C1-9heteroaryl, C1-6heteroarylaminocarbonyl, C1-6ureido, C1-6thioureido, C1-4alkylcarbonyloxy, C1-4alkoxycarbonyloxy, C1-4alkoxysulfonyloxy, C1-6heterocycloalkyloxy, C1-6 alkylthio, C1-6aminosulfonyl, C1-6aminocarbonyloxy, C1-6alkylsulfonylamino, C1-6 alkylsulfonylamino C1-3alkyl, C6-10arylamino, C6-10arylaminocarbonyl, C6-10aryloxycarbonyl, C1-4alkoxycarbamoyl, C6-10 arylcarbonylamino, C6-10arylsulfonylamino, C1-6alkylcarbonylamino, C2-6alkenylcarbonylamino, C3-6cycloalkenylcarbonylamino, C3-6cycloalkylcarbonylamino, C1-6alkoxycarbonylamino, C1-6heterocycloalkylcarbonylamino, C1-6alkylsulfonyl, C1-6heterocycloalkylsulfonyl or C1-4alkylsulfonylaminocarbonyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, aminoC1-6alkyl, C1-6haloalkyl, C3-7cycloalkyl, C3-7cycloalkenyl, C1-6heterocycloalkyl, C2-6heterocycloalkenyl, or carboxyC6-10aryl are optionally substituted with one or more, same or different substituents selected from the group consisting of halogen, trifluoromethyl, hydroxy, cyano or C1-4alkyl;
• R2 represents one or more, same or different substituents selected from hydrogen, cyano, halogen, carboxy, —C(O)NH2, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, aminoC1-6alkyl, C3-6cycloalkyl, C1-6heterocycloalkyl, C1-6alkoxy, C1-6aminocarbonyl, C6-10aryloxycarbonyl, C1-6amino, C6-10 arylamino, C1-4 alkoxycarbonylamino, C1-4 alkylcarbonylamino, C2-4 alkenylcarbonylamino, C3-6 cycloalkylcarbonylamino or C1-6 heterocycloalkylcarbonylamino,
• or pharmaceutically acceptable stereoisomers, salts or in vivo hydrolysable esters thereof.