Heteroaryl substituted indole compounds useful as MMP-13 inhibitors

A compound of the formula (I):

• Het is a ring chosen from phenyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, pyrazolyl, pyrrolyl, imidazolyl, pyridinyl, pyrimidinyl and pyridazinyl each optionally substituted by one to three C1-5 alkyl, C1-5 alkoxy, C1-5 acyl, C1-5 acylamino, amino, cyano, hydroxyl or halogen;
• X is —N(R3)—;
• Y is N or CH;
• Z is H or F;
• R1 is chosen from C1-5 alkoxyC1-5 alkyl, C1-5 alkoxycarbonyl-(CH2)n—, —C(O)NR4R5 and Ar1;
• R2 is chosen from Ar2—(CH2)n—, heterocycle and C1-5 alkyl;
• R3 is chosen from hydrogen and C1-5 alkyl;
• each R4 and R5 is independently chosen from hydrogen, C1-5 acyl, C1-5 alkyl, C1-5 alkoxy, hydroxyl, carbocycle-(CH2)n—, heteroaryl and heterocycle-(CH2)n—;
• Ar1 is chosen from carbocycle, heteroaryl and heterocycle wherein Ar1 is optionally substituted by one to three C1-5 alkyl, C1-5 alkoxy, C1-5 acyl, C1-5 acylamino, amino, cyano, hydroxyl or halogen;
• Ar2 is chosen from carbocycle, heteroaryl and heterocycle wherein Ar2 is optionally substituted by one to three heteroaryl, C1-5 alkyl, C1-5 alkoxy-(CH2)n—, C1-5 alkoxycarbonyl-(CH2)n—, carboxy-(CH2)n—, C1-5 acyl, C1-5 acylamino, amino, cyano, hydroxyl, sulfonyl, sulfoxide, thio, oxo or halogen;
• each n is independently 0-2;
• or a pharmaceutically acceptable salt thereof.