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US 8,785,463 B2Granted
GPR 119 agonists
AssigneeCadila Healthcare Limited
InventorsHarikishore Pingali, Pandurang Zaware
Life of this patent
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Abstract
The present invention relates to novel GPR 119 agonists of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
Claims12
A compound of formula (I),
- its tautomeric form, its stereoisomer, and pharmaceutically acceptable salt thereof
- wherein
- R1 represents H or an optionally substituted group selected from a member of the group consisting of linear or branched (C1-C6)-alkyl, haloalkyl, (C1-C6)alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroarylalkyl, alkylsulfonyl, and arylsulfonyl groups, or a group represented by (CH2)mCO2R4, (CH2)mCOR4 or (CH2)mCONH2 wherein each R4 independently represents H or a group selected from a member of the group consisting of linear or branched (C1-C6)alkyl, cycloalkyl, aryl, heterocyclyl and heteroaryl;
- and m is an integer of 0 to 3;
- R2 represents H, cyano, nitro, formyl, linear or branched (C1-C6) alkyl, or (C1-C6) alkoxyl;
- R3 represents an optionally substituted group selected from a member of the group consisting of linear or branched (C1-C6)alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroaralkyl or a group represented by C(O)OR5, C(O)R5, and SO2R5 wherein each R5 independently represents H or an optionally substituted group selected from a member of the group consisting of linear or branched (C1-C6)alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, hererocyclylalkyl, heteroaryl, and heteroaralkyl groups;
- n represents an integer from 0 to 3;
- and
- “A” represents
- wherein p represents an integer from 1 to 3;
- and X represents O or S.
8 more elements
Dependencies are inferred from the claim text.