5-hydroxypyrimidine-4-carboxamide derivative

A compound represented by formula (1):

• wherein,
• R1 represents a group represented by formula (1A):
• wherein,
• R4 and R5 each independently represents a hydrogen atom, a halogen atom or a C1-C6 alkyl group,
• R6 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a carbamoyl group, a C1-C6 alkylcarbamoyl group, or a (C1-C6 alkyl)(C1-C6 alkyl)carbamoyl group,
• R7 represents a hydroxy C1-C6 alkyl group which may have 1 or 2 substituents independently selected from substituent group α, a hydroxyhalo C1-C6 alkyl group which may have 1 or 2 substituents independently selected from substituent group α, a C1-C6 alkoxy C1-C6 alkyl group which may have 1 or 2 substituents independently selected from substituent group α, a (C1-C6 alkoxy)carbonyl group which may have 1 or 2 substituents independently selected from substituent group α, a C1-C6 alkoxy C1-C6 alkoxy C1-C6 alkyl group which may have 1 or 2 substituents independently selected from substituent group α, a hydroxy C1-C6 alkoxy group which may have 1 or 2 substituents independently selected from substituent group α, a C1-C6 alkylcarbamoyl group which may have 1 or 2 substituents independently selected from substituent group α, a (C1-C6 alkyl)(C1-C6 alkyl)carbamoyl group which may have 1 or 2 substituents independently selected from substituent group α, a C1-C6 alkoxycarbamoyl group which may have 1 or 2 substituents independently selected from substituent group α, a C1-C6 alkylcarbamoyl C1-C6 alkyl group which may have 1 or 2 substituents independently selected from substituent group α, a (C1-C6 alkyl)(C1-C6 alkyl)carbamoyl C1-C6 alkyl group which may have 1 or 2 substituents independently selected from substituent group α, a C2-C7 alkanoylamino group which may have 1 or 2 substituents independently selected from substituent group α, a C2-C7 alkanoylamino C1-C6 alkyl group which may have 1 or 2 substituents independently selected from substituent group α, or a C2-C7 alkanoyloxy C1-C6 alkyl group which may have 1 or 2 substituents independently selected from substituent group α,
• substituent group α represents a group consisting of an oxo group, a hydroxy group, an amino group, a carboxy group, a carbamoyl group, a C1-C6 alkoxy group, a halo C1-C6 alkoxy group, a C2-C7 alkanoylamino group, a hydroxyimino group, and a C1-C6 alkoxyimino group,
• ring Q1 represents a monocyclic heterocyclic group, wherein the heterocyclic group comprises a 5- to 7-membered aromatic heterocycle and non-aromatic heterocycle, and contains 1 or 2 atoms selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom,
• ring Q2 represents a monocyclic hydrocarbon ring group, wherein the hydrocarbon ring group comprises a 5- to 7-membered aromatic hydrocarbon ring and a non-aromatic hydrocarbon ring, or a monocyclic heterocyclic group, wherein the heterocyclic group comprises a 5- to 7-membered aromatic heterocycle and non-aromatic heterocycle, and contains 1 or 2 atoms selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom,
• ring Q3 represents a monocyclic hydrocarbon ring group, wherein the hydrocarbon ring group comprises a 5- to 7-membered aromatic hydrocarbon ring and a non-aromatic hydrocarbon ring, or a monocyclic heterocyclic group, wherein the heterocyclic group comprises a 5- to 7-membered aromatic heterocycle and non-aromatic heterocycle, and contains 1 or 2 atoms selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom, and
• X represents a single bond, methylene, or ethylene,
• R2 represents a C1-C3 alkyl group or a methylsulfanyl group, and
• R3 represents a hydrogen atom or a methyl group, a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt thereof.