Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

A compound represented by formula (Ib)

• wherein
• R is a group —CORa, —CONHRa or —CONRaRb wherein Ra and Rb are, each independently, hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl or;
• together with the nitrogen atom to which they are bonded, Ra and Rb may form an optionally substituted 5 or 6 membered heterocycle optionally containing one additional heteroatom or heteroatomic group selected among N, NH, O or S;
• R1 is selected from the group consisting of:
• straight or branched C3-C4 alkyl;
• cycloalkyl, cycloalkyl-alkyl or alkyl-cycloalkyl wherein the cycloalkyl moiety comprises any C3-C6 cycloalkyl group and wherein the alkyl moiety comprises any straight or branched C1-C4 alkyl group:
• 3-methylthienyl-2-yl;
• 2-thienyl;
• phenyl;
• 2,6-difluorophenyl;
• 4-(aminosulfonyl)phenyl;
• 4-(dimethylaminomethyl)phenyl;
• 4-(4-methylpiperazinyl)methyl-phenyl;
• a group of formula (IIa) or (IIb):
• wherein, the formula (IIa), the cycle represents a 5 to 7 membered heterocyclic ring wherein X, directly linked to the rest of the molecule, represents a carbon or nitrogen atom;
• Y is a carbon, nitrogen, oxygen or sulfur atom or it is an NH group, provided that at least one of X and Y is other than a carbon atom;
• Rc is, independently from each other and in any one of the free positions of the heterocyclic ring of formula (IIa), a halogen atom or hydroxy group or it is an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, amino, aminocarbonyl, carboxy, oxo (═O), alkoxycarbonyl, alkylcarbonyl or arylcarbonyl;
• and n is 0 or an integer from 1 to 4;
• a group of formula (IIc) or (IId):
• wherein Rd, R′d and Re represent, the same or different and independently from each other, a hydrogen atom or a straight or branched C1-C6 alkyl optionally substituted by one or more groups selected from hydroxy (—OH), aminocarbonyl (—CONH2) or methylaminocarbonyl (—CONHCH3);
• or a pharmaceutically acceptable salt thereof.

A library of two or more compounds of formula (Ib)

• wherein
• R is a group —CORa, —CONHRa or —CONRaRb wherein Ra and Rb are, each independently, hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl or;
• together with the nitrogen atom to which they are bonded, Ra and Rb may form an optionally substituted 5 or 6 membered heterocycle optionally containing one additional heteroatom or heteroatomic group selected among N, NH, O or S;
• R1 is selected from the group consisting of:
• straight or branched C3-C4 alkyl;
• cycloalkyl, cycloalkyl-alkyl or alkyl-cycloalkyl wherein the cycloalkyl moiety comprises any C3-C6 cycloalkyl group and wherein the alkyl moiety comprises any straight or branched C1-C4 alkyl group:
• 3-methylthienyl-2-yl;
• 2-thienyl;
• phenyl;
• 2,6-difluorophenyl;
• 4-(aminosulfonyl)phenyl;
• 4-(dimethylaminomethyl)phenyl;
• 4-(4-methylpiperazinyl)methyl-phenyl;
• a group of formula (IIa) or (IIb):
• wherein, in formula (IIa), the cycle represents a 5 to 7 membered heterocyclic ring wherein X, directly linked to the rest of the molecule, represents a carbon or nitrogen atom;
• Y is a carbon, nitrogen, oxygen or sulfur atom or it is an NH group, provided that at least one of X and Y is other than a carbon atom;
• Rc is, independently from each other and in any one of the free positions of the heterocyclic ring of formula (IIa), a halogen atom or hydroxy group or it is an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, amino, aminocarbonyl, carboxy, xoxo (═O), alkoxycarbonyl, alkylcarbonyl or arylcarbonyl;
• and n is 0 or an integer from 1 to 4;
• a group of formula (IIc) or (IId):
• wherein Rd, R′d and Re represent, the same or different and independently from each other, a hydrogen atom or a straight or branched C1-C6 alkyl optionally substituted by one or more groups selected from hydroxy (—OH), aminocarbonyl (—CONH2) or methylaminocarbonyl (—CONHCH3);
• or a pharmaceutically acceptable salt thereof.